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KMID : 0604520060320040241
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Journal of the Society of Cosmetic Scientists of Korea
2006 Volume.32 No. 4 p.241 ~ p.247
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Studies on the Anti-inflammatory Activity of Paulownia coreana Uyeki Leaf Extract
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Kim Nam-Kyung
Kim Mi-Hwa
Yoon Chang-Soon
Choi Shin-Wook
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Abstract
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This work was carried out to investigate the anti-inflammatory effects of Paulownia coreana Uyeki on abirritant, atopy and acne skin. Paulownia coreana Uyeki has been used as a traditional medicine having anti-febrile, anti-inflammation effect in Korea, Paulownia coreana Uyeki loaves were extracted with 70% EtOH. Its superoxide anion radical scavenging activity and inhibitory effect on LPS-induced NO production were examined. The extract inhibitied the generation of NO and PGE_2 induced by LPS in the macrophage cell line (Raw 264.7). Consistent with the inhibitory effects on No and PGE_2 generation, the extract inhibited expression of iNOS and COX-2. In further study, it was found that the extract prevented IkB-{alpha} degradation, as demonstrated by western blot analysis of IkB-{alpha} protein level. However, the extract treatment did not affect cell viability at 100{mu}g/mL concentration in both human skin fibroblast and Raw 264.7 cells in vitro. Thus, the present study suggests that Paulownia coreana Uyeki leaves extract have significant anti-inflammatory activity and potential as an anti-irritation material.
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KEYWORD
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anti-inflammatory effect, superoxide anion radical scavenging activity, Paulownia coreana Uyeki, IkB-{alpha}
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